To directly test theHistamine Receptor contribution of Scgb1a1(+) Clara cells to postnatal development, homeostasis, and fix of lung epithelium, we generated a Scgb1a1-CreER (TM) "knockin" mouse for lineage-tracing these cells. Beneath all problems examined, the vast majority of Clara cells during the bronchioles the two self-renews and generates ciliated cells. Within the trachea, Clara Selinexor (KPT-330) cells give rise to ciliated cells but tend not to self-renew extensively. Nonetheless, they can contribute to tracheal fix. During the postnatal mouse lung, it has been proposed that bronchioalveolar stem cells (BASCs) which coexpress Scgb1a1 (Secretoglobin1a1) and SftpC (Surfactant Protein C), contribute descendants to the two bronchioles and alveoli. The putative BASCs have been lineage labeled in our studies. However, we come across no evidence for your function of a unique BASC population in the course of postnatal development, adult homeostasis, or fix. Rather, our final results help a model by which the trachea, bronchioles, and alveoli are maintained by distinct populations of epithelial progenitor cells.